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Psoriasis involves nearly all the skin cells and inflammatory cells. It alters the set of complex interactions that control skin homeostasis: interactions between the dermis and the epidermis; interactions between inflammation, proliferation and differentiation; control of proliferation and epidermal differentiation by the immune system; control of proliferation, differentiation and inflammatory and immune responses by the nervous system and neurotransmitters; involvement of the microcirculation in maintaining the inflammation chronic; the role of genetic conditions and the expression of the genes in the skin’s response to attacks. The physiopathology of psoriasis can be described from each and every one of the above. In fact, research on the understanding of the psoriasis physiopathology is like piecing together a jigsaw puzzle: it can be reconstructed from every single one of its pieces.

Psoriasis involves virtually all the skin cells and inflammatory cells. It alters the set of complex interactions that controls skin homeostasis : interactions between the dermis and the epidermis ; interactions between inflammation, proliferation and differentiation ; control of proliferation and epidermal differentiation by the immune system ; control of proliferation, differentiation and inflammatory and immune responses by the nervous system and neurotransmitters ; involvement of the microcirculation in maintaining the inflammation chronic ; the role of genetic conditions and the expression of the genes in the skin’s response to attacks. The physiopathology of psoriasis can be described on the basis of each and every one. In fact, researching our understanding of the physiopathology of psoriasis is like piecing together a jigsaw puzzle : it can be reconstructed from every single one of its pieces.

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