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Home > PORTAL > Psoriasis: consensus and controversies > THE PHYSIOPATHOLOGY OF PSORIASIS >

Psoriasis is the outcome of an anomaly of the interactions between dermis and epidermis

[|There is no experimental proof
that the disturbance between epidermis and dermis is responsible for the
development of psoriasis.|auteur194]

The psoriatic fibroblasts, taken from both lesional and non-lesional skin, are capable of inducing hyperproliferation of normal keratinocytes. The molecules responsible for this phenomenon are being studied. Psoriatic patients’ serum contains unidentified molecules capable of accentuating this phenomenon. The destruction of superficial dermal cells by burn or CO2 laser sometimes ends up eliminating the psoriasis plaque for good. These biological and clinical arguments are strong enough to believe that some anomaly in the superficial dermal fibroblasts is the initial anomaly behind psoriasis. However, the superficial dermis contains more than just fibroblasts, and the selective destruction of capillary anomalies observed in the superficial dermis of psoriatic lesions by pulsed dye laser often results on skin cleaning. Interestingly, the remission length is far better in old lesions, very resistant to treatments.

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